I read about NAD+ and was sceptical at first, but I think there must be something to it! I'm currently using my second pouch, haven't noticed much change (though I'm lucky enough to say that I almost never have issues with my skin; I'm just hoping to preserve its youthful appearance for as long as possible - as we all probably do, whether we want to admit it or not ;-)). I would love to continue taking these capsules and observing their possible longtime influence, but they seem to be constantly unavailable:-(